脂源性细胞因子与子痫前期关系的研究

Study of relationship between adipocytokine and preeclampsia.

目的:探讨子痫前期(PE)患者血清脂源性细胞因子(脂联素和瘦素)水平的变化及其意义。方法:以53例子痫前期孕妇为研究组(其中轻度子痫前期32例、重度子痫前期21例),20例同期分娩的正常孕妇为对照组。采用ELISA法检测血清脂联素和瘦素水平。同时检测血清甘油三脂(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)水平。结果:(1)轻度、重度子痫前期患者血清脂联素水平分别为8.88±4.67μg/m l及5.14±2.79μg/m l,明显低于对照组11.61±2.90μg/m l,差异有统计学意义(P<0.01)。而轻度、重度子痫前期患者血清瘦素水平为21.79±15.19ng/m l及27.27±18.38ng/m l,明显高于对照组的12.35±6.51ng/m l,差异有统计学意义(P<0.05,P<0.01),(2)子痫前期患者血清脂联素与TG、TC、LDL-C、HDL-C均显著相关(r分别为-0.658、-0.624、-0.419、0.461),瘦素水平也与上述指标显著相关(r分别为0.534、0.707、0.418、-0.513),(3)子痫前期患者血清脂联素及瘦素水平呈高度负相关(r=-0.760,P<0.01)。结论:脂联素、瘦素等脂源性细胞因子在PE的发病中可能起一定的作用。

Objective：To explore the role of adipocytokine, adiponectin and leptin in the pathogenesis of preeclampsia （PE）. Methods： The serum levels of adiponectin and leptin were measured using the enzyme-linked immunosorbent assay in 53 preeclampsia（PE） patients and 20 normal pregnant women. Seventy-three women were divided into three groups：group A consisted of 20 normal pregnant women （NPW） ;group B consisted of 32 women with mild preeclampsia （MPE）;and group C consisted of 21 women with severe pre-eclampsia （SPE）. Results ：The serum levels of adiponectin in women with MPE or SPE were significantly lower （ 8.88±4.67 μg/ml, 5.14±2.79 μg/ml, respectively ） than those in NPW （ 11.61±2. 90 μg / ml;P 〈0.01 ,P 〈 0.01 ,respectively）. While the serum levels of leptin in women with MPE or SPE were significantly higher than those in NPW（ MPE ：21.79±15.19ng/mL vs 12. 35±6.51ng/ ml,P 〈0. 05;SPE：27.27±18.38ng/ml vs 12. 35±6. 51ng/ml,P 〈 0. 01 ）. In the preeclamptic women serum levels of triglycerides （ TG）, total cholesterol （ TC ） and low-density lipoproteincholesterol（ LDL-C ） were significantly increased （ P 〈 0. 01 ）, while high-density lipoproteincholesterol （ HDL-C ） were significantly decreased than those in normal pregnant women （ P 〈 0. 01 ）. Serum levels of adiponectin were correlated significantly with TG, TC, and LDL-C, HDLC in pre-eclamptic women（ r = - 0. 658, P 〈 0. 01 ; r = - 0. 624, P 〈 0.01 ; r = - 0. 419, P 〈 0. 05 ;r = 0.461, P 〈 0.05, respectively ）. In addition, serum levels of leptin were significantly correlated with the serum levels of TG, TC, and LDL-C, HDL-C in pre-eclamptic women （r =0. 534,P 〈0.05;r =0.707,P 〈0.01 ;r =0.418,P 〈0. 05 ;and r = -0. 513,P 〈0.01,respec- tively）. There was a negative correlation between the serum levels of adiponectin and leptin in preeclamptic women（ r = -0. 760 ,P 〈0.01 ）. Conehmion： Adiponectin and leptin may be involved in the pathogenesis of PE. Moreover, reduced serum concentrations of adiponectin and elevated leptin are associated with the development of this disease.