中枢神经损伤与异位骨化

RELATIONSHIP BETWEEN THE CENTRAL NERVOUS SYSTEM INJURY AND THE HETEROTOPIC OSSIFICATION

目的综述近阶段国内外有关中枢神经损伤后异位骨化研究的新进展。方法广泛查阅近期有关中枢神经损伤与异位骨化研究的文献,综述神经性异位骨化的危险因素、发病率、发病机制、临床症状和体征、诊断及预防治疗。结果神经性异位骨化可能的机制与骨形成蛋白和成纤维细胞生长因子有关。超声、肌酸磷酸激酶、C-反应蛋白已经在临床上用于检测异位骨化的发生。秋水仙碱和罗非考昔可以用来预防和治疗异位骨化。结论神经性异位骨化的研究取得了长足进展,但还需要进一步研究。

Objective To review the progress of the research on the relationship between the central nervous system injury and the heterotopic ossification. Methods The recent articles on the central nervous system injury and the heterotopic ossification were extensively reviewed, and the related clinical signs, symptoms, pathogenesis diagnosis, risk factors, prophylaxis, and treatment of the neurogenic heterotopic ossification were investigated. Results The possible mechanism for the neurogenic heterotopic ossification might involve the roles of the bone morphogenetic protein and the basic fibroblast growth factor, which were suggested as mediators in differentiation of the progenitor cells. Sonographic, serum creatine phosphokinase, and C-reactive protein were recommended as the useful screening tools for heterotopic ossification. Colchicine and rofecoxib could be used for the prophylaxis or treatment of heterotopic ossification. Conclusion The research on the neurogenic heterotopic ossification has achieved a great development but further studies in this field are still required.