Reversing gastric mucosal alterations during ethanol-induced chronic gastritis in rats by oral administration of Opuntia ficus-indica mucilage

瞄准：为了学习，粘液的效果在在老鼠导致乙醇的胃炎愈合上从仙人掌属植物 ficus-indica (仙人掌科) 的叶状枝获得了。方法：长期的胃粘膜损害与粘液被对待(5 mg/kg 每天) 在它被乙醇导致以后。类脂化合物作文， 5'-nucleotidase (联系膜的 ectoenzyme ) 的活动和在胃粘膜的血浆膜的 lactate 和醇脱氢酶的 cytosolic 活动是坚定的。从试验性的组的胃的样品的组织学的研究被包括。结果：乙醇得到了表面上皮的损失和 polymorphonuclear 的渗入描绘的胃炎的组织学的侧面。Phosphatidylcholine (PC ) 减少了，胆固醇内容在胃粘膜的质膜增加了。另外，当醇脱氢酶的活动减少了时， cytosolic 活动增加了。粘液的管理即时改正了这些酶的变化。事实上，粘液乐意地在胃粘膜的质膜加速了导致乙醇的组织学的改变和骚乱的恢复，显示出只有一个意义的反煽动性的效果。5'-nucleotidase 的活动在类脂化合物作文和胃的粘膜质膜的流动性与变化相关。结论：粘液的有益的行动似乎与损坏胃粘膜的质膜的稳定相关。在粘液之间的分子的相互作用单音的糖类和膜 phospholipids，主要 PC 和 phosphatidylethanolamine (PE ) ，可以是负责在长期的胃的粘膜以后在愈合的过程期间改变依附膜的蛋白质的活动的相关特征损坏。

AIM： To study the effect of mucilage obtained from cladodes of Opuntia ficus-indica （Cactaceae） on the healing of ethanol-induced gastritis in rats. METHODS： Chronic gastric mucosa injury was treated with mucilage （5 mg/kg per day） after it was induced by ethanol. Lipid composition, activity of 5＇-nucleotidase （a membrane-associated ectoenzyme） and cytosolic activities of lactate and alcohol dehydrogenases in the plasma membrane of gastric mucosa were determined. Histological studies of gastric samples from the experimental groups were included. RESULTS： Ethanol elicited the histological profile of gastritis characterized by loss of the surface epithelium and infiltration of polymorphonuclear leukocytes. Phosphatidylcholine （PC） decreased and cholesterol content increased in plasma membranes of the gastric mucosa. In addition, cytosolic activity increased while the activity of alcohol dehydrogenases decreased. The administration of mucilage promptly corrected these enzymatic changes. In fact, mucilage readily accelerated restoration of the ethanol-induced histological alterations and the disturbances in plasma membranes of gastric mucosa, showing a univocal anti-inflammatory effect. The activity of 5＇-nucleotidase correlated with the changes in lipid composition and the fluidity of gastric mucosal plasma membranes. CONCLUSION： The beneficial action of mucilage seems correlated with stabilization of plasma membranes of damaged gastric mucosa. Molecular interactions between mucilage monosaccharides and membrane phospholipids, mainly PC and phosphatidylethanolamine （PE）, may be the relevant features responsible for changing activities of membrane-attached proteins during the healing process after chronic gastric mucosal damage.