1During MJ,Xu R,Young D,Kaplitt MG,Sherwin RS,Leone P.Peroral gene therapy of lactose intolerance using an adeno-associated virus vector.Nat Med,1998,4:1131~1135.
2Brown GR,Thiele DL,Silva M,Beutler B.Adenoviral vectors given intravenously to immunocompromised mice yield stable transduction of the colonic epithelium.Gastroenterology,1997,112:1586~1594.
3Man AL,Prieto-Garcia ME,Nicoletti C.Improving M cell mediated transport across mucosal barriers:do certain bacteria hold the keys? Immunology,2004,113:15~22.
4Ye X,Jerebtsova M,Ray PE.Liver bypass significantly increases the transduction efficiency of recombinant adenoviral vectors in the lung,intestine,and kidney.Hum Gene Ther,2000,11:621~627.
6Cheng DY,Kolls JK,Lei D,Noel RA.In vivo and in vitro gene transfer and expression in rat intestinal epithelial cells by E1-deleted adenoviral vector.Hum Gene Ther,1997,8:755~764.
7Wirtz S,Galle PR,Neurath MF.Efficient gene delivery to the inflamed colon by local administration of recombinant adenoviruses with normal or modified fibre structure.Gut,1999,44:800~807.
8Schmiedlin-Ren P,Kesisoglou F,Mapili JA,Sabek SE,Barnett JL,Chey WD,Roessler B,Zimmermann EM.Increased transduction of human intestinal epithelial cells by adenoviral vectors in inflammatory bowel disease.Inflamm Bowel Dis,2005,11:464~472.
9Nakahira M,Ahn H J,Park WR,Gao P,Tomura M,Park CS,Hamaoka T,Ohta T,Kurimoto M,Fujiwara H.Synergy of IL-12 and IL-18 for IFN-gamma gene expression:IL-12-induced STAT4 contributes to IFNgamma promoter activation by up-regulating the binding activity of IL-18-induced activator protein 1.J Immunol,2002,168:1146~1153.
10Barbulescu K,Becker C,Schlaak JF,Schmitt E,Meyer zum Buschenfelde KH,Neurath MF.IL-12 and IL-18differentially regulate the transcriptional activity of the human IFN-gamma promoter in primary CD4 + T lymphocytes.J Immunol,1998,160:3642~3647.