6—取代吲哚喹嗪酮的^1H NMR

THE ￣1H NMR OF 6-SUBSTITUTED INDOLOQUINOLIZIDONES

６位取代的３—乙酰基—１，４，６，７—四氢吲哚［２，３—ａ］喹嗪—４—酮具有抗肿瘤活性．活性强度与６位取代基相关．本文报道了６—甲氧羰基、６—羰基、６—酰胺基、６—羟甲基和６—乙酰基乙酰氧甲基取代的３—乙酰基—１，４，６，７—四氢吲哚［２，３—ａ］喹嗪—４—酮的１ＨＮＭＲ，比较了所述化合物的抗ＨＬ６０活性与某些质子的化学位移的关系．

The 6-substituted 3-acety1-1,4,6,7-tetrahydro-4-oxoindolo-[2,3-a]quinolizines exhibited antitumer activity and the potency related to 6 substituent.In the present paper 6-methoxycarbonyl-,6-carboxy-,6-amido-,6-hydroxymethyl-and 6-acetylacetomethy1-3-acety1-1,4,6,7-tetrahydro-4-oxoindolo [2,3-a]quinolizine were synthesized,their 1H NMR are reported,the relationships between HL60 inhibitions and the chemical shifts for some protons are discussed.