驱镉剂N—（d—葡萄糖基）—L—氨基酸类化合物的^1H NMR谱研究

￣1H NMR STUDY ON N-GLUCAMYL-AMINO ACIDS AS CADMIUM CHELATING AGENTS

ｄ－葡萄糖与Ｌ－氨基酸缩合制得一类新型驱隔剂，本文报道５种Ｎ－（－葡萄糖基）－Ｌ－氨基酸的１ＨＮＭＲ．当氨基酸侧链上有含羟基、巯基及苄基一类的富电荷基时，葡萄糖基上的质子都移向高场．这可能与这些基团的存在不利于Ｎ－取代氨基酸生成内盐有关．动物实验表明：与甘氨酸的衍生物比较，它们的驱镉性能也较优秀，本文推测，不利于生成内盐的基因也可能有助于发挥驱镉效应．

A series of novel cadmium chelating agent, N-glueamyl-amino acids were synthesized. In the present paper their 1￣H NMR data are reported. The results indicate that when amino acid contain hydroxyl, thiol or benzy1 group as the side chain,the protons of glucamyl will shift up field. Perhaps these groups are disadvantageous for the formation of the internal salts of amino acids and will be responsible for the up field shift mentioned. The bioassy shows that these compounds containing special side chain are better than glycine derivative on cadmium excretion.