摘要
d-葡萄糖与L-氨基酸缩合制得一类新型驱隔剂,本文报道5种N-(-葡萄糖基)-L-氨基酸的1HNMR.当氨基酸侧链上有含羟基、巯基及苄基一类的富电荷基时,葡萄糖基上的质子都移向高场.这可能与这些基团的存在不利于N-取代氨基酸生成内盐有关.动物实验表明:与甘氨酸的衍生物比较,它们的驱镉性能也较优秀,本文推测,不利于生成内盐的基因也可能有助于发挥驱镉效应.
A series of novel cadmium chelating agent, N-glueamyl-amino acids were synthesized. In the present paper their 1 ̄H NMR data are reported. The results indicate that when amino acid contain hydroxyl, thiol or benzy1 group as the side chain,the protons of glucamyl will shift up field. Perhaps these groups are disadvantageous for the formation of the internal salts of amino acids and will be responsible for the up field shift mentioned. The bioassy shows that these compounds containing special side chain are better than glycine derivative on cadmium excretion.
出处
《波谱学杂志》
CAS
CSCD
1996年第5期443-446,共4页
Chinese Journal of Magnetic Resonance
基金
卫生部基金
中科院武汉物理研究所波谱与原子分子物理国家重点实验室资助
关键词
葡萄糖
氨基酸
驱镉剂
NMR
D-Glucose
L-Amino acid
Cadmium chelating agent
 ̄1H NMR