1—[2—^3H[（2—羟基—3—甲氧丙基）—2—硝基—1H—咪唑的制备

PREPARATION OF 1-[2-￣3H](2-HYDROXY-3-METHOXYPROPYL-2-NITRO-1H-IMIDAZOLE

以ＮａＢ３Ｈ４还原１－（２－氧－３－甲氧丙基）－２－硝基－１Ｈ－咪唑制得１－［２－３Ｈ］（２－羟基－３－甲氧丙基）－２－硝基－１Ｈ－咪唑（简称３Ｈ－ＭＩＳＯ）．产品经硅胶－Ｈ柱洗脱、蒸馏、Ｓｅｐ－ＰａｋＣ１８柱处理，并经ＨＰＬＣ及液闪检测，化学纯度＞９９．９％，放射化学纯度＞９７％，比活度为１６．０５ＴＢｑ／ｍｏｌ。

he synthesis of tritium-labelled miSOnidazole (3H-MISO) via the NaB3H4 reduction of 1-(3-(methoxy-2-oxopropyl)-2-niro-1H-imidazole is described. The obtained product is treated with silica gel Column,distillation and Sep-Pak C18 columm HPLC shows that the chemical purity of the productis more than 99. 9% and its radiochemical purity is more than 97%. The specific activity of the product is 16. 05TBq/mol,as determined by HPLC and liquid scintillation counting.