摘要
在过去的十年中，铜放射性药物的研究大都集中在心肌和脑的显像剂、肿瘤诊断药物及单抗药物，主要是双缩氨基硫脲类药物及其类似物，并对Ｃｕ－ＰＴＳＭ的滞留机制进行了研究。还可以制备其它类型（如ＢＡＴ类）的中性铜放射性药物，以期得到铜的脑放射性药物。
In the past decade most of the efforts of copper radiopharmaceuticals research has been focused onbis (thisoemicartheonato) copper complexes for use in myocardial and brain imaging agents. In the present work, the analogs of bis(thiosemicarbazone) is studied in labeling antibodies and tumors. The retention mechanism of Cu-PTSM is investigated. Other kinds of ligands, BAT(N2S2) for example, canbe used to prepers neutral copper complexes in order to obtain brain radiopharmaceuticats in future.
出处
《同位素》
CAS
北大核心
1996年第3期167-178,共12页
Journal of Isotopes
关键词
铜
放射性药物
心肌
脑显像剂
单克隆抗体
copper radiopharmaceuticals. myocardial and brain imaging agent monoclonal antibody bis (thisosemicarbazonato) copper pharmaceutical retention mechanism
