血清多不饱和脂肪酸与高脂血症的关系分析

ANALYSES ON THE RELATIONSHIP BETWEEN SERUM POLYUNSATURATED FATTY ACIDS AND HYPERLIPEMIA (ABSTRACT)

观测了大连市175例50岁上下两年龄组成人血清三脂酰甘油、磷脂、胆固醇及各种脂肪酸含量。并对高脂血与ω-3型多不饱和脂肪酸水平的关系,特别是与花生四烯酸(AA)、二十碳五烯酸(EPA)或二十二碳六烯酸(DHA)之间的关系作了分析。结果表明大连居民血清中主要脂肪酸组成基本符合文献报道中沿海城市的类型。但EPA和DHA明显偏低。在体内他们虽然可从其它营养必需脂肪酸少量转化而来,但远远不能满足机体的需要,故人体所需EPA和DHA主要靠摄入。本文分析显示EPA和DHA与TG、TC的水平呈负相关。故EPA/AA和DHA/AA的比值可作为ω-3系多不饱和脂肪酸摄取及预测心血管疾病的指标,对营养调理及临床防治疾病有指导意义。

Analyses of serum triglyceride(TG), phospholipids(PL), cholesterol(Ch)and various fatty acids in two age-groups of 175 adult Dalianese havebeen conducted. The relationship between ω-3 polyunsaturated fattyacid (PUFA) levels and hyperlipemia and those between arachidonicacid(AA) and eicosapentaenoic or docosahexoenoic acids (EPA, DHA)have been investigated. The results show that the content of saturatedfatty acids of urban people in Dalian is close to that reported onliteratures, whereas content of ω-3 PUFA is significantly lower thanthat of urban people in Japan. Thus, ω-3 PUFAs, such as EPA andDHA, as nutritionally necessary fatty acids, are consumed not in anenough amount. Furthermore, it has been found that EPA and DHAcontents are in negative correlation with serum TG and total Ch. Thisfact is an evidence that EPA and DHA can be lower serum TG and Chlevels, and thus the EPA and DHA are effective in prevention andcuring of angiocardiopathy. This paper shows that the presence ofEPA and DHA leads to many useful metabolites and contributes togood effects. Thus, the ratios of EPA/AA and DHA/AA may beconsidered as the criteria of the intake level of ω-3 PUFAs and thepremonitory parameters for thrombotic coronary heart diseases.