双侧髂内动脉内保留导管灌药治疗难治性卵巢癌

INTRA-ARTERIAL PERFUSION OF CHEMOTHERAPY VIA RETENTION CATHETER IN BILATERAL INTERNAL ILIAC ARTERIES FOR REFRACTORY OVARIAN CARCINOMA (ABSTRACT)

本组5例难治性卵巢癌,4例为第二次手术后盆腔内复发,1例为Ⅲ期癌只行活检。经用多疗程顺铂为基础的全身化疗无效后采用双髂内动脉保留导管灌药。顺铂30～40mg/日5次,联用阿霉素20mg/日5次,或联用环磷酰胺200mg/日5次。2例获显效,2例有效,1例无效。动脉内给药量大于静脉用药(20mg/日5次),然毒副反应不重于静脉用药。本文还对插管的解剖学、药代动力学的依据及是否并用栓塞进行了讨论。

5 cases of refractory ovarian carcinoma were treated with intra-arterial chemotherapy via preserved catheter inserted into bilateralinternal iliac arteries. All the patients had failed to several courses ofcisplatin-base systemic chemotherapy prior to this methode. Pelvicrecurrence found in 4 of them after the second operation. The anothergot a biopsy only and was diagnosed as a stage Ⅲ ovarian carcinoma.Cisplatin 30～40mg/day combined with either ADM 20mg/day or CTX200mg/day were administered for arterial perfusion via the preservedcatheter for 5 days. Effect was observed in 4 cases. Despite the largerdrug dose in the arterial perfusion the toxicity is the same as that inthe intravenous infusion. The regional anatomy for inserting thecatheter into bilateral iliac arteries and the pharmacokinetics of drugwere discussed.