摘要
本文应用高效液相色谱法分析34例胃癌病人尿多胺含量,并与19例胃良性溃疡病人及23名正常人对比。结果表明胃癌病人尿多胺含量明显高于胃良性溃疡病人和正常人。有淋巴结转移和肝转移的胃癌病人尿多胺含量明显高于无淋巴结转移和肝转移的胃癌病人。胃癌根治切除术后病人尿多胺含量比术前明显降低。尿多胺含量与胃癌病理分化程度无明显关系。我们认为尿多胺含量测定对胃癌辅助诊断,术前预测肿瘤转移及监测治疗效果有一定的临床意义。
Urinary excretion of spermidine and putrescine was measured by HPLCin 34 patients with gastric cancer,19 with gastric ulcer and 23 normalsubjects.The results showed that polyamine levels in the urine of gastriccancer were significantly higher than that of gastric ulcer and thenormal.The polyamine levels in node-positive cases were significantlyhigher than in node-negative cases.The polyamine levels were signifi-cantly higher in patients with liver metastases compared with patientswithout liver metastases.After successful surgical removal of tumour,polyamine levels of gastric cancer patients decreased significantly ascompared with the preoperative values.Urinary polyamine excretiondid not correlate with histologic differentiation.Our preliminarydata indicate that determination of polyamine may be useful in tumourdiagnosis,predicting metastases and monitoring response to therapy.
关键词
高效液相色谱
胃癌
多胺
胃肿瘤
high performance
liquid chromatography
gastric cancer
polyamine
