生长激素联合肝动脉化疗栓塞治疗肝癌的临床观察

THE CLINICAL OBSERVATION OF REORGANIZED-HUMAN GROWTH HORMONE ASSOCIATE WITH TACE IN PRIMARY LIVER CANCER.

目的：对比分析单用肝动脉化疗栓塞（TACE）和TACE联合重组人生长激素（γ-hGH）治疗原发性肝癌的近期疗效。方法：24例原发性肝癌病例随机分为两组，单用TACE组（对照组）12例和TACE联合γ-hGH组（研究组）12例。对照组接受TACE，表阿霉素35-40mg/m^2，加碘化油栓塞剂。而研究组接受以上治疗外，于治疗的1-5d接受γ-hGH治疗。监测治疗前、治疗的不同时间的生化指标、氮平衡、整体营养状况评分、生活质量评分和近期疗效。结果：2组病例的肝肾功能无差异；治疗的d3、d8研究组的白蛋白、前白蛋白、转铁蛋白水平高于对照组；治疗的d3、d7，研究组的氮平衡高于对照组；治疗的14d、28d，研究组的营养状况较对照组好；接受TACE治疗后1周、2周的生活质量评分，研究组明显高于对照组（P〈0．05）；TACE后4周的疗效评价2组之间无差异。结论：-hGH联合TACE治疗原发性肝癌，能提高病人的营养状况、病人的生活质量和病人的氮平衡。肝肾功能不受影响，联用γ-hGH不降低疗效。

Objective： To analyze contrastively biochemical index, nitrogen- balance, nutrition status, quality of lire and short - term response in primary liver cancer Daitents for comparing the treatment effect of single liver artery chernoembolization （TACE） with reorganized human growth hormone （γ- hGH） associate with TACE.Methods： 24 patients with primary liver cancer were randomly divided into TACE group （control group, 12 cases） and TACE associate with γ - hGH group （study group, 12 cases） . The patients in control group were only treated with TACE. Besides TACE, the patients in study group were treated with γ - hGH, additionly. The biochemical indexes, nitrogen- balance index, the whole nutrition status grade, the quality of life and short - term response were studied. Result： There was no statistical difference between the two groups in liver and kidney＇s index, but the level of albumin, prealbumin and transferring albumin in study group were higher than control group. The nitrogen - balance and nutrition status in study group were better than that of control group, the grade of QOL in study group was higher than that of control group. There was no statistiea significant difference between the two groups in response rate. Conclusion： γ- hGH associate with TACE in primary liver cancer could improve the patient＇s nutrition status grade, QOL grade and nitrogen- balance, but there is no influence on liver and kidney＇ s index and r- hGH associate with TACE can＇ t attenuate response rate.