布-加综合征患者血清5项生化指标联合检测的临床意义

THE CLINICAL SIGNIFICANCE OF FIVE BIOCHEMICAL ITEM IN BUDDCHIARI SYNDROME.

目的:探讨血清总胆汁酸(TBA)、总胆红素(TBIL)、前白蛋白(PAB)、胆碱酯酶(CHE)及α-谷氨酰基转移酶(GGT)在布-加氏综合征诊断及治疗中的价值。方法:采用全自动分析仪测定80例布-加氏综合征病人及80例正常人血清中TBA、TBIL、PAB、CHE、GGT浓度,并对检测结果进行统计学分析。结果:布-加氏综合征病人血清TBA、TBIL、GGT水平显著增高(P<0.01);PAB、CHE水平显著降低(P<0.01)。布-加氏综合征组中PAB阳性率为84%明显高于ALB;TBA、TBIL、CHE及GGT阳性率分别为78%、76%、83%及58%,明显高于ALT(P<0.01)。结论:PAB、TBA、TBIL、CHE及GGT能更敏感地反映布-加氏综合征病人肝脏受损情况,为该疾病的诊断、治疗提供了更有价值的生化指标。

Objective： To discuss the value of serum total bile acid （TBA）, total bilibrubin （TBIL）, pre- albumin （PAB）, cholinesterase and GGT in diagnosing and treatment for Budd - Chiari syndrome. Methods： Serum samples of 80 Budd - Chiari syndrome cases and 80 healthy cases were examined by auto biochenlical analyzer and analyzed by statistical methods. Results： The level of TBIL, TEA., GGT in Budd - Chiari syndrome cases were significantly higher than that in healthy cases （P〈0.01） The level of PAB, CHE in Budd- Chiari syndrome cases were significantly lower （P〈0.01） Positive rate of PAB was 84% which was higher than ALB in Budd - Chiari syndrome cases （P〈0.01） Positive rate of TBA, TBIL, CHE and GGT were 78%, 76%, 83% and 58% respectively, all were higher than that of ALT （P〈0.01） Conclusion： The level of PAB, TBA, CHE and GGT in serum are more sensitive that can reflect liver injury of Budd - Chiari syndrome, which are valuable biochemical makers for its diagnosis and treatment.