氟哌利多、格拉司琼预防腹腔镜胆囊切除术后恶心呕吐疗效观察

Clinical Observation on Droperidol and Granisetron in Preventing Postoperative Nausea and Vomiting after Laparoscopic Cholecystectomy

目的:比较氟哌利多、格拉司琼预防腹腔镜胆囊切除术后恶心呕吐的临床疗效。方法:选择120例ASAⅠ一Ⅱ级择期腹腔镜胆囊切除术病人,按入院编号随机分为三组,各40例。A组诱导前5 m in静注氟哌利多2.5 mg,B组在开始缝皮前静注格拉司琼3 mg、C组(对照组)静注生理盐水10 mL。结果:术后24 h内恶心呕吐发生率A组17.5%、B组15%,明显低于C组50%(P<0.05),A组与B组比较差异无显著性(P>0.05)。结论:氟哌利多和格拉司琼均可显著降低腹腔镜胆囊切除术后恶心呕吐发生率。

Objective：To evaluate the prophylactic effect of granisetron and droperidol on postoperative nausea and vomiting （PONV） of laparoscopic cholecystectomy （LC）. Methods： One hundred and twenty LC patients were randomly divided into three groups,which received an intravenous bolus of 0.9% NS 10 ml （placebo, group , C , n = 40）, droperidol 2.5 mg （ droperidol group , A, n = 40）, granisetron 3 mg （ granisetron group , B , n = 40）, respectively. Results： The incidences of PONV in group A （ 17.5% ） and group B （ 15 % ） were significantly lower than those in group C 50% （P 〈 0.05 ）in postoperative 24 hours. There was no significant difference between group A and B （ P 〉 0.05 ）. Conclusion： Both dropefidol and granisetron can be used effectively to prevent PONV in LC patients.