维生素D受体基因多态性与肺结核关系的Meta分析

Meta-analysis of relationship of vitamin D receptor polymorphism and tuberculosis

目的 分析维生素D受体基因多态性与肺结核易感性的病例对照研究的结果。方法应用Meta—analysis，以Fleiss模型和DerSimonian and Nan Laird模型（D—L模型）对6项研究结果进行数据处理。结果累计病例841例，对照1419例，采用Fleiss模型计算的合并OR值ff vs FF为1．20（0．84-1．71），Ff vs FF为0．99（0．81～1.21），D—L模型计算的合并OR值ff vs FF为1．12（0．67-1．86），Ff vs FF为0．99（0．80-1.23）。失效安全数小于1。结论尚不能认为维生素D受体基因多态性是肺结核易感性的影响因素。

Objective To quantitatively analyze the results of case - control study on vitamin D receptor gene （ VDR ） polymorphism and the susecptibility of tuberculosis by means of Meta - analysis. Methods Fleiss＇ s model and Der simonian and Nan Laird＇ s model （D - L＇s model） were applied in the process of the data, Results The cumulative cases and controls were 841 and 1419, respectively, The pooled OR were 1.20（0.84 - 1.71 ）for ff vs FF and 0.99 （0.81 - 1.21 ） for Ff vs FF in Fleiss＇ s model and 1.12（ 0.67- 1.86 ） for ff vs FF and 0.99（ 0.80- 1.23 ） for Ff vs FF in D- L＇s model. Fail- safe Number is less than 1. Conclusion There is no significant correlation between VDR gene polymorphisms and the susecptibility of pulmonary tuberculosis.