摘要
目的 了解广州地区犬伤特点,选择比较不同种抗狂犬病疫苗的免疫效果,为疫苗的选择和狂犬病的防治提供科学依据。方法抽取2005年1~12月份治疗的犬伤者1083人,根据登记记录,了解犬伤特点,对伤口给予正确处理,按就诊者意愿选择接种人用狂犬病纯化疫苗(地鼠肾细胞)(甲组)及人用VERO细胞狂犬病疫苗(冻干疫苗)(乙组),并在全程接种疫苗后2周采血,检测抗狂犬病毒抗体水平,比较免疫效果和副反应发生率。结果犬伤者男性多于女性,以上肢、单处伤和浅层伤多见;10d内伤口愈合者占绝大多数;免疫后乙组抗体阳性率90.2%高于甲组73.7%,差异有显著性(P〈0.05);甲组异常反应高于乙组,差异有显著性(P〈0.05)。结论伤口经正确处理.可在短期内愈合,甲组和乙组疫苗都有较好的免疫水平,建议在检测和抢救条件稍差的基层单位,最好选择异常反应较少的冻干狂犬病疫苗。
Objective To survey the feature of wounds bitten by dogs in Guangzhou City and analyze the results of immunization. Methods 1 083 patients bitten by dogs were divided into Group A immunized with full course of homemade human rabies vaccine and Group B immunized with imported Vero cell rabies vaccine respectively, Antibody levels were monitored 2 weeks after regular vaccination. Side - effect after immunization with the two vaccines were observed, Results More male patients were bitten than female ones, The seroconversion rates 2 weeks after immunization with imported Vero - cell vaccine in Group B was 90.2% and only 73.7 % in Goup B immunization with homemade vaccine ( P 〈 0.05). In addition, less side effects were observed in Group B (P 〈 0.05), Conclusion Higher immune levels were observed in both of Group A and B, It is suggested that imported Vero cell vaccine be chosen by medical units at grassroots level where medical facilities are relatively poor.
出处
《中国热带医学》
CAS
2006年第8期1392-1393,1412,共3页
China Tropical Medicine
关键词
狂犬病疫苗
免疫效果
抗体
疫苗接种
Rabies vaccine
Results of immunization
Antiboby
Vaccination