血浆D-二聚体测定在老年糖尿病中的临床意义

Significance of determination of plasma D-dimers in senile diabetes patients

目的探讨D-二聚体在老年糖尿病中临床意义。方法采用ELISA法测定90例老年2型糖尿病血浆D-二聚体(DD)及凝血因子VIII相关抗原(VIIIR:Ag)和纤维蛋白原(Fbg)含量变化,观察合并血管病变与治疗前后的变化。结果老年糖尿病合并血管病变组血浆DD、VIIIR:Ag和Fbg含量均明显高于正常组(P<0.001)和无血管场变组(P<0.01);经治疗后血浆DD、VIIIR:Ag和Fbg含量均明显降低(P<0.01),但仍高于正常组(P<0.05)。结论老年糖尿病合并血管病变血浆D-二聚体等含量增高,动态监测血浆D-二聚体等指标对于早期发现和预防老年糖尿病合并血管病变有一定临床意义。

Objective To study the clinic significance of changes of plasma levels of D - dimer, coagulation factor Ⅷ and Fbg in elderly diabetic patients. Methods Enzyme Linked Immunosorbent Assay（EIISA） was used to detect the plasma levels of Ddimer, coagulation factor ⅧR：Ag and Fbg in 90 elderly diabetic patients with and without angiopathy. Results The levels of DD, IIIR：Ag and Fbg of elderly diabetic patients with angiopathy were significantly higher than that of normal subjects （ P 〈 0.001 ） and patients without angiopathy （ P 〈 0.01 ）. After treatment, the levels of DD,ⅧR： Ag and Fbg of elderly diabetic patients with angiopathies were significantly decreased （ P 〈 0.01 ）. Conclusion The detection of plasma levels of DD in elderly diabetic patients is of clinical significance early diagonsis and provention of angiopathy.