金香丹片对冠心病心绞痛患者血栓前状态的影响

Effect of Jinxiangdan Tablets on the Pre-thrombus State of Patients with Coronary Heart Disease and Angina Pectoris

目的探讨金香丹片对冠心病心绞痛患者血栓前状态的治疗价值。方法临床诊断冠心病心绞痛患者166例,随机分成治疗组与对照组,观察两组治疗前后血浆纤维蛋白原(Fg)、血管性假性血友病因子(vWF)、P-选择素(P-selectin)、D-二聚体(D-dimer)、组织型纤溶酶原激活剂(t-PA)、血管内皮损伤因子内皮素(ET-1)的变化。结果治疗前冠心病心绞痛患者Fg、vWF、P-selectin、D-dimer、ET-1均升高,t-PA降低,金香丹片治疗后可降低Fg、vWF、P-selectin、D-dimer、ET-1水平,升高t-pA水平。结论金香丹片能改善患者凝血纤溶系统及内皮细胞分泌功能,降低血小板活化状态,对预防心血管事件有疗效。

Objective To discuss the treatment value of Jinxiangdan tablets on the pre-thrombus state of patient with coronary heart disease and angina pectoris. Methods 166 cases of clinical diagnosed coronary heart disease and angina pectoris were randomly divided into the treatment group and the control group. The changes of Fg, vWF, P-selectin, D-dimer, t-PA, ET- 1 of two groups before and after the treatment were observed.Results Before the treatment, Fg, vWF, P-selectin, D-dimer and ET-1 elevate, while t-PA reduces. After the treatment of Jinxiangdan, Fg, vWF, P-selectin, D-dimer and ET-1 were decreased, t-pA were increased. Conclusion Jinxiangdan tablets can improve the hemoglutination fibrinloytic system and secretion function of endothelial cell, reduce the activity of platelet, to prevent the cardiovascular events.