阿尔茨海默病与人体铝等四种化学元素及其相关因素的病例对照研究

Case-control study of Alzheimer's disease with four chemical elements and relevant factors

目的初步探讨化学元素（铝、铜、锌、钙）和相关因素对阿尔茨海默病的影响。方法采用1：1配对病例对照研究，在南昌及九江地区共选择确诊的AD病人129例，并以性别、年龄（±3岁）、文化程度及居住环境作为配对条件，选择健康对照129例。收集相关的资料进行多因素条件logistic回归分析。结果提示经常使用铝制炊具、性格孤僻、重大不良生活史是AD的危险因素，OR值及其95％CI分别为2．454（1．277～5．268）、2．486（1．075～6．638）和4．125（1．706～12．249）；家庭经济状况良好和积极参加体育锻炼是AD的保护因素，OR值及其95％CI分别为0．324（0．106～0．828）和0．258（0．104～0．520）。结论长期使用铝制炊具、性格孤僻、重大生活不良史与AD患病有关，家庭经济状况良好、积极参加体育锻炼对抵御AD有积极作用。

Objective To explore chemical elements （Al, Cu, Zn, Ca） and relevant factors of Alzheimer＇s disease （AD）. Methods A 1 ： 1 matched case-control study was conducted. 129 patients with Alzheimer＇s disease and 129 healthy controls were selected in Nanchang and Jiujiang areas. The conditioned logistic regression was used to analyze the date. Results According to the results of multivariate analysis, using utensils made of Aluminum （ OR = 2. 454, 95% CI = 1. 277 - 5. 268）, the unsociable personality （ OR = 2. 486, 95 % CI = 1. 075- 6. 638）, severe negative history of life events （ OR = 4. 125, 95 % CI = 1. 706- 12. 249） were identified as risk factors for Alzheimer＇ s disease, The good family economic status （ OR = 0. 324, 95 % CI = 0. 106 -0. 828） and active physical exercises （OR =0.258, 95% CI =0.104-0.520） were protective for Alzheimer＇s disease. Conclusions Using utensila made of Aluminum, unsociable personality, severe negative history of life events were important hazardous behaviors for AD; good family economic status and active physical exercises was positive related to AD.