益脑安对癫痫大鼠惊厥行为干预的实验研究

The Experimental Study of Yinao'an (益脑安) for Cerebral Excitatory Amino Acid in Epilepic Rats

目的观察益脑安对癫痫大鼠惊厥行为干预的作用,初步探讨其治疗癫痫的机理。方法用PTZ点燃大鼠癫痫模型,动物随机分组,分别用益脑安、丙戊酸钠、益脑安+丙戊酸钠灌胃,观察大鼠的癫痫发作级别、发作次数及发作持续时间。结果益脑安组、丙戊酸钠组以及益脑安+丙戊酸钠组对PTZ点燃的癫痫模型大鼠的发作级别、发作次数及发作持续时间均有一定的抑制作用,其中又以益脑安组最为明显。结论益脑安可以通过抑制惊厥行为的发作级别、发作次数而起到PTZ点燃大鼠的抗癫痫作用。

Objective:To explore the mechanism of Yinao'an(益 脑 安 ) on the treatment of epilepsy, by observing the function of Yinao' an to the epilepic rats.Methods:Except for control group, the other rats were established epilepsy model by pentatetrazole(PTZ). The model were allocated to Yinao' an group, sodium valproste group,Yinao' an and sodium valproste group and model group randomly, perfused with Yinao' an sodium valproste, Yino' an sodium valproste. Observing the level, definitely, and duration of epilepsy.Results:Yinao' an and SV group can control the level, degree,and duration of epilepsy definitely, especially the Yinao' an group. Conclusion:Yinao' an can restrain the epilepsy.