氯敌鼠钠盐对长爪沙鼠急性毒力的研究

Study on Acute Toxicity of Chlorophacine-Na Against the Meriones unguiculatus

目的测定氯敌鼠钠盐对长爪沙鼠(Meriones unguiculatus)的急性毒力。方法依据孙氏改良寇氏综合计算法,以测致死中量(LD50)的方式,配制5个浓度梯度的氯敌鼠钠盐药液供给试鼠;试验采用经口一次灌胃法。结果测得其LD50值为0.325mg/kg,标准误为0.058,其95%平均可信限为(0.325±0.085)mg/kg;试鼠性别、体重、死亡时间各项指标经方差检验差异均无统计学意义(P>0.05)。结论按毒力分级标准,氯敌鼠钠盐对长爪沙鼠急性毒力达到极毒水平,在实际鼠防工作中可作为慢性毒药的补充,也可独立使用。

Objective To test the acute virulence of chlorophacine-Na against Clawed jird（ Meriones unguiculatus ）. Methods The M. unguiculatus were treated with the toxicant in 5 consistencies infused in stomach according as the method of Improved Kou＇s Integrated Way by Sun＇s in laboratory. Results The LDs0 of chlorophacine-Na in M. unguiculatus was 0. 325 mg/kg and the standard error was 0. 058. The confidence limit on 95 % was （0. 325±0. 085） mg/kg. By F test, there was no significant difference（P 〉 0.05） on the efficiency of the acute virulence between sex. Conclusion The acute toxicity of chlorophacine-Na against M. unguiculatus comes veriest toxic by the graded standard of toxicant against mice and it revealed that its acute toxicity can be used as complementarities of the chronic virulence or even by itself in controlling mice.