奥扎格雷纳对心肌梗死患者甲襞微循环和血液流变学的影响

Effects of Sodium Ozagrel on Nail Microcirculation and Hemorrheology in Patients with Myocardial Infarction

目的观察奥扎格雷纳（丹奥）对心肌梗死患者甲襞微循环和血液流变学变化的影响.方法 128例心肌梗死患者随机分为丹奥治疗组（A组）68例和对照组（B组,）60例.在常规治疗基础上,A组加用丹奥（80～160 mg/d）,B组加用葡萄糖、胰岛素和氯化钾液（250～500 ml/d）,疗程10～14 d.观察两组患者治疗前后的甲襞微循环和血液流变学变化.结果治疗组用药后甲襞微循环各项指标和血液流变学变化均明显优于对照组（ P＜0.01）.结论奥扎格雷纳可明显改善心肌梗死患者的甲襞微循环和血液流变学指标.

Objective To observe the effects of sodium ozagrel on nail microcirculation and hemorrheology in patients with myocardial infarction （MI）. Methods 128 MI cases were randomly divided into the treatment group （group A, n= 68） and control group （group B, n=60）. On the base routine treatment, patients of group A were treated with sodium ozagrel （80～160 mg/d） and those of group B were treated with glucose-insulin-potassium solution （250～500 ml/d）. The changes of nail microcirculation and hemorrheology were measured in pre-treatment and post-treatment. Results The nail microcirculation and hemorrheology in group A were significantly better than group B （ P〈0.01）. Conclusion Sodium ozagrel can markedly improve nail microcirculation and hemorrheology in patients with MI.