参脉注射液治疗老年非ST段抬高心肌梗死急性期的疗效观察

Effects of Shengmai Injection on Myocardial Infarction without Initial ST Elevation in Senile Patients

目的探讨参脉注射液对老年非ST段抬高心肌梗死(NSTEMI)急性期的疗效及作用机制。方法68例老年急性非ST段抬高心肌梗死病人随机分为两组,除常规心肌梗死治疗外,参脉组每天静脉注射30mL参脉,刺五加组每天静脉注射刺五加400mg,疗程4周,于用药前后监测心肌酶、心电图与血液流变学等指标。结果参脉组总有效率91.2%,显著高于刺五加组(80.0%),在降低心肌酶、改善心电图及血液流变学方面的作用均优于刺五加组(P<0.01)。结论参脉注射液对老年非ST段抬高心肌梗死急性期的治疗效果好,副反应少,临床疗效显著。

Objective To infarction without initial mechanisms Methods evaluate the effects of Shenglnai Injection on myocardial ST elevation （MIWSTE） in senile patients （pts） and its Sixty senile pts with MIWSTE were assigned to two groups randomly. Shengmai group was treated with Shengmai Injection. Ciwujia group was treated with Ciwujia Injection with the basic therapies. Hemorrheology, ∑ST ↓ , HR, SBP, Killip grade, CK and CK - MB in two groups were measured pre - and post - therapy. Results The total efficiency rate in Shengmai group and Ciwujia group were 92.1% and 80.0 %, The effects of improvement on CK, ECG and hemorrheology in Shengmai group were markedly higher（P 〈 0.01 ）than that in Ciwujia group, but the side effects of Shengmai were not significantly higher. Conclusion Shengmai Injection was more effective and less side effect than Ciwujia Injection for the treatment of NSTEMI in senile pts. The mechanisms might be myocardial protection, reducing blood viscosity and improving microcireulation.