缺血修饰白蛋白、肌红蛋白和肌钙蛋白联合检测诊断早期急性心肌梗死

Rapid quantitative analysis of ischemia modified albumin,myohemoglobin and cardiac troponin Ⅰ for early diagnosis of acute myocardial infarction

目的探讨缺血修饰白蛋白(IMA)、肌红蛋白(Mb)、肌钙蛋白(CTnI)联合检测对急性心肌梗死(AMI)的早期诊断评价。方法连续监测急性胸痛者225例,入院后分别于即刻、3h、6h、9h、24h测定IMA、Mb、CTnI三项指标,观察其变化规律。结果即刻测定IMA、Mb、CTnI敏感性分别为89.6%、78.0%、55.0%,联合检测敏感性为94.6%。两者比较有显著性差别(P<0.05)。在9h内联合检测敏感性均高于单项检测,有显著性差异(P<0.05)。结论IMA、Mb、CTnI联合检测诊断急性心肌梗死,其敏感性明显优于单项检测,具有重要的临床应用价值。

Objective To Investigate the value of rapid quantitative analysis of ischemia modified album （IMA） and myohemoglobin （Mb） and cardiac Troponin I（CTnI） in early acute mycoardial infarction. Methods The variation laws were observed by continuously measuring IMA, Mb and CTnI of two hundred and twenty-five patients with acute chest pain at 0,3,6,9,24 hours after admission respectively. Results The sensitivity value were 89.6% for IMA, 78.0% for Mb and 55.0% for CTnI. The specificity was 94.6% with the co-detection of IMA combined Mb and CTnI. It was remarkable difference compared two groups （P 〈 0.05）. The sensitivity of co-detection was remarkable higher than that any single detection in nine hours admission （P 〈 0.05）. Conclusions The co-dection of IMA, Mb and CTnI surpasses obviously the single detection, and has the extremely vital clinical significance.