抗环瓜氨酸肽抗体检测在类风湿性关节炎的临床应用研究

A study on anti-cyclic citrullinated peptide antibody in patients with rheumatoid arthritis

目的探讨抗环瓜氨酸肽抗体(抗CCP抗体)检测在类风湿性关节炎(RA)患者的诊断及临床意义。方法研究对象为211例RA患者及对照组为40例健康体检者,采用ELIAS法检测抗CCP抗体、速率散射比浊法检测类风湿因子(RF),并对其结果进行回顾性分析。结果①211例RA患者检测抗CCP抗体和RF结果阳性率分别为73.93%(156/211)和63.51%(134/211),其分别与对照组比较,经χ2检验,P<0.01结果均有非常显著性意义,抗CCP抗体与RF组间比较,则P<0.05结果有显著性意义。②211例RA患者及对照组检测RF结果分别为113.28±218.5IU/ml和9.24±15.02IU/ml,结果组间比较,经t检验,P<0.01结果有非常显著性意义。结论抗CCP抗体与RA病情严重程度及其发展有关,可作为RA临床检测新的血清学指标。与RF联合检测,再结合临床症状可提高RA的检出率,抗CCP抗体检测用于早期诊断,对RA早期诊断具有非常重要的临床意义。

Objective To study the determination and clinical significance of anti-cyclic citrullinated peptide （anti-CCP） in patients with rheumatoid arthritis （RA）. Methods Serum anti-CCP and RF from 211eases of RA and 40 controls were determined by ELISA. Results Of 211 eases of RA, the positive rates of anti-CCP and RF were 73.93% and 63.51%, and both resuits were much higher than those in the controls （P 〈 0.01）. The results of RF were 113.28 ± 218.5 IU/ml and 9.24 ±15.02 IU/ml in RA and control groups respectively, and with significantly defferent（P 〈 0.01）. Conedusions The results suggest that the determination of anti-CCP has a certain value for early diagnosis and treatment of RA.