米氮平与曲唑酮、马普替林治疗抑郁症对照研究

Study of the Treatment of Depression with Mirtazapine, Trazodone and Maprotine

目的:评价米氮平与曲唑酮、马普替林治疗抑郁症的疗效及不良反应。方法:将符合《中国精神障碍分类与诊断标准》第3版诊断标准的抑郁症住院和门诊患者121例,随机平分为三组,分别给予米氮平和曲唑酮、马普替林治疗,疗程6周。用汉密尔顿抑郁量表(HAMD)、汉密尔顿焦虑量表(HAMA)、临床疗效总评量表的病情严重程度(CGI—S1)和不良反应量表(TESS),评定疗效和不良反应。结果:6周治疗后,3组总分均有显著下降,3组间疗效比较差异无统计学意义(P>0．05)。结论:米氮平能更迅速的起效,对抑郁症的各个症状均有突出表现,是一种安全、有效的抗抑郁药。

Objective： To compare the efficacy and side effects of remeron, trazodone and maprotine in the treatment of depression, Method： In this study, 121 patients with diagnostic depression according to CCMD-3 were randomly assigned to remeron group, trazodone group and maprotine group and the treatment lasted 6 weeks. Their effects and side reactions were evaluated by means of HAMD, HAMA, CGI-SI and TESS before and after the treatment. Result： Remeron produced quicker effects and its side effects were fewer than those of trazodone and maprotine. Conclusion： Remeronh rapid effect is prominent on all symptoms of depression, Remeron is an effective and safe antidepressant.