洛美沙星注射液中脱羧产物1－乙基－6，8－二氟－1，4－二氢－7－（3－甲基－1－哌嗪基）－4－氧代喹啉的分离与鉴定

ISOLATION AND IDENTIFICATION OF 1-ETHYL-6, 8-DIFLUORO-1,4-DIHYDRO-7-(3-METHYL-PIPERAZIN-1-YL)-4-OXOQUINOLINE,A DECARBOXYLATED COMPOUND FROM LOMEFLOXACIN INJECTION

从洛美沙星注射液中分离出一种有机杂质，经紫外及红外光谱、高分辨质谱、核磁谱等鉴定为１－乙基－６，８－二氟－１，４－二氢－７－（３－甲基－１－哌嗪基）－４－氧代喹啉，即洛美沙星的脱羧物，该化合物未见文献报道，

An organic impurity was isolated from lomefloxacin injection using column and thin layer chromatography. The chemical structure was elucidated by UV, IR, MS,￣1HNMR, and ￣(13)CNMR and Shown as 1-ethyl-6,8-difluoro1,4-dihydro-7-(3-methylpiperazin-1-yl)-4-oxoquinoline, which has not been reported in literature.