摘要
以正常人新鲜冰冻血浆作原料,采用低温乙醇Cohn5法相6法进行对照性中量试生产。结果表明,Cohn6法所得白蛋白半制品的3批收率平均为2.44±0.1g/100ml血浆,纯度平均为98.6±0.6%,分别比Cohn5法提高0.12g/100ml血浆和1%;就分离白蛋白而言,Cohn6法较Cohn5法更为理想。
Using normal fresh frozen human plasma as raw material,the low temperature processes of Cohn method 6 and 5 were compered in pilot plant scale production.According to the results obtained from 3 batches in each method,the average yield of semi-finished albumin products of method6 were 2.44±0.10g/100ml plasma with 98.6±0.6% purity,which were 0.12g/100ml plasma in yield and 1% in purity higher than those of methat 5. So method 6 was more reasonable than method 5 for the separation process of albumin.
出处
《中国医药工业杂志》
CAS
CSCD
北大核心
1996年第10期437-439,共3页
Chinese Journal of Pharmaceuticals
关键词
人血白蛋白
低温乙醇
human plasma albumin,Cohn method 6 and 5,Cohn fractions PIV-1 and PIV-4