新型纳米粒给药系统——纳米结构的脂质载体

New nanoparticle delivery system:nanostructured lipid carriers

固体脂质纳米粒(SLN)已被公认是一种新型的纳米粒给药系统,但SLN有不同程度的潜在问题。作为新一代的纳米粒给药系统——纳米结构的脂质载体(Nanostructured lipid carriers,NLC)可减小或者避免SLN有限载药能力及储藏过程包封药物泄漏的问题,而且能调整SLN的释放曲线。NLC以固体脂质与物态上相异的液体脂质混合制备得到,形成3种类型特殊结构的脂质骨架:结晶不完全态、无定形态、复合态。现介绍一种特殊的制备方法,不仅适合于制备NLC,而且也可作为制备高粒子浓度(30%～95%)SLN分散液的方法。描述了NLC作为给药系统潜在的应用前景。

Solid lipid nanoparticles （SLN） have been introduced as a novel nanoparticulate delivery system. Potential problems associated with SLN such as limited drug loading capacity, adjustment of drug release profile and potential drug expulsion during storage are avoided or minimized by the introduction of new generation of SLN-nanostructured lipid carriers （NLC）. NLC are produced by mixing solid lipids with spatially incompatible lipids leading to Special structures of the lipid matrix, i.e. three types of NLC-the imperfect structured type, the structureless type and the multiple type. A special preparation process applicable to NLC but also SLN allows the production of highly concentrated particle dispersions （30% -95% ）. Potential applications as drug delivery system were described.