醋氯芬酸中有机溶剂残留量的GC测定

Determination of residual organic solvents in aceciofenac by GC

目的:建立了毛细管气相色谱法测定醋氯芬酸中的甲醇、乙酸乙酯、甲苯、DMF等残留溶剂的含量。方法:用CP-624(30m×0．32mm,1．8μm)色谱柱,柱温100℃,进样口温度220℃,检测器温度300℃,载气为氮气,进样量1mL。结果:各溶剂的线性关系良好(r均在0．999以上);平均回收率99．6%～100．5%。结论:本实验建立的色谱方法灵敏、准确,适用于醋氯芬酸中残留有机溶剂的检测。

Objective： To set up a capillary GC method for the determination of residual organic solvents （methanol, ethyl acetate, toluene, N, N-dimethylformamide） in aceclofenac. Methods： The GC condition was as follows： a CP-624 column （30 m×0. 32 mm,1.8μm） with a column temperature at 100℃, the temperature of the loading chamber at 220℃, detection temperature at 300 ℃ , nitrogen as a carrier gas and loading dose of 1 mL. Results：The calibration curves of four solvents were linear （r 〉 0. 999） with mean recoveries of 99.6% -100. 5%. Conclusion：The sensitive and reliable GC method for determination of residual solvents in aceclofenac is attainable.