摘要
目的观察两种促排卵结合宫腔内人工授精对不孕症的治疗效果。方法对97例不孕症患者142个月经周期促排卵治疗,随机分为两组,克罗米芬(CC)+倍美力74例(107周期),CC+人绝经期尿促性腺激素(HMG)23例(35周期),卵泡成熟时用人绒毛膜促性腺激素(hCG)诱发排卵联合丈夫精子宫腔内人工授精(AIH/IUI),总结不同促排方案治疗效果及促排卵过程发生的异常反应。结果CC+倍美力+hCG组、CC+HMG+hCG组的临床妊娠率为13·5%和39·1%、周期妊娠率为9·4%和25·7%,两组比较差异均有统计学意义(P<0·05)。排卵日CC+倍美力+hCG组与CC+HMG+hCG组非妊娠组的子宫内膜厚度分别为(8·9±1·5)mm和(10·3±1·7)mm,发育卵泡个数(1·6±0·7)个和(2·2±1·0)个,两组比较差异均有统计学意义(P<0·01);而妊娠组排卵日子宫内膜厚度分别为(10·±1·7)mm和(10·2±1·5)mm,发育卵泡个数为(1·8±0·8)个和(2·3±1·0)个,两组比较差异均无统计学意义(P>0·05)。结论两种促排方案结合IUI/AIH是治疗不孕症的有效方法,而CC+HMG+hCG联合用药更有效地改善子宫内膜和多个卵泡发育,提高妊娠率。
Objective To observe the effect of two methods of promoting ovulation associating with uterus intracavitary. Methods 97 barren women （menstual cycles） ,were divided into 2 groups randomly. One group （74 cases） was given cc＋ BML,the another group （23 cases）was given cc ＋ HCG. All were given HCG to induce ovulation and husband spermatozoa uterus intracavitary artifificial insemination （AIH/IUI）when ovarian follides matured. Therapeutic efficacy and side effects were observed. Results The clinical pregnancy rate was 13.5 % and 39.1% in the CC ＋ BML ＋ HCGand CC ＋ HMG ＋ HCG respectively. The period pregnancy rate was 9.4 % and 25.7 % respectively（ P 〈 0.05）. Endometrial thickness was（ 8.9 ±1.5 ） ram and（ 10.3 ±1.7） mm in the groups of CC ＋ BML ＋ HCG and CC ＋ HMG ＋ HCG. Developed ovarian follides were （ 1.6 ＋ 0.7） and （2.2 ＋ 1.0） ; While endometritum thickness was （ 10.0 ± 1.7）mm and（ 10.2 ±1.5）mm in BML pregnancy group and CC peegant group,Developed ovarian follides was （1.8±0.8） and （2.3±1.0）. Condusion Both methods are effetive in treating infertility,while CC ＋ HMG ＋ hCG are more offcient by better stimulating the growth of endometrium and ovarian follides.
出处
《广西医学》
CAS
2006年第7期971-974,共4页
Guangxi Medical Journal
基金
广西壮族自治区卫生厅科研课题[桂卫Z9839]
