神经阻滞与苯巴比妥治疗失眠对照研究

COMPARISON OF THE EFFICACY OF NERVE BLOCK AND PHENOBARBITAL IN THE TREATMENT OF INSOMNIA

目的:神经阻滞与苯巴比妥治疗失眠的疗效比较。方法:将128例失眠患者随机分为神经阻滞组和苯巴比妥组各64例。神经阻滞组采用神经阻滞(星状神经节阻滞+双枕大神经阻滞),每日一次,15次为一疗程。苯巴比妥组每晚睡前30min口服苯巴比妥分别为15mg、30mg、60mg,最大剂量达90mg,15天为一疗程。观察两组疗效的差别。结果:神经阻滞组和苯巴比妥组在治疗一疗程后与治疗前比较差异非常显著(P<0.01)。治疗后两组间比较差异也非常显著(P<0.01)。结论:神经阻滞治疗失眠疗效明显优于口服苯巴比妥,且神经阻滞组治愈率高,复发率低,副作用少,无耐药性和依赖性。

Objective： To assess the efficacy and safety of treatment with nerve block and phenobarbital in patients with insomnia. Methods： 128 patients suffered from insomnia were randomly assigned into nerve block group （stellate ganglion plus bilateral great occipital nerve block, once a day for 15 days） or oral phenobarbital group （ 15, 30, and 60 mg before night sleep with the maximum dose of 90 mg, lasting 15 days）. Results： For both groups, significant improvements were obtained after treatment （P 〈 0. 01 ）. Nerve block treatment showed a better effect than oral phenobarbital （P 〈 0. 01 ）. Conclusion： Treating insomnia with nerve block is more effective than phenobarbital, with an advantage of fewer side effects.