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脑挫裂伤患者脑脊液ApoE多态性与周围脑组织水肿的关系 被引量：2

The relationship between cerebrospinal fluids' ApoE polymorphism and brain edema in the contusion and laceration of brain
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摘要 目的探讨脑挫裂伤患者脑脊液载脂蛋白E基因(ApoE)多态性与周围脑组织水肿的关系。方法用聚合酶链反应-限制性片段多态性(PCR-RFLP)技术检测36例脑挫裂伤患者ApoE基因型频率,根据CT片计算脑水肿指数,统计学分析它们之间的关系。结果脑水肿指数与ApoE3呈负相关,而与ApoE4呈正相关,两者都具有统计学意义,脑挫裂伤患者脑脊液ApoE3和ApoE4与周围脑组织水肿具有相关性。结论脑挫裂伤患者脑脊液ApoE多态性可能是影响周围脑组织水肿的因素之一。 Objective To study the relationship between cerebrospinal fluids＇ apolipoprotein E （ApoE） polymorphism and brain edema in the contusion and laceration of brain. Methods The cerebrospinal fluids＇ApoE genetic polymorphism was detected using polymerase chain reaction restriction fragment length polymorphism （PCR-RFLP） technique and the edema index was estimated by CT in 42 patients with contusion and laceration of brain. Results The ApoE genetic polymorphism of cerebrospinal fluids was closely related to the brain edema in patients with contusion and laceration of brain. Conclusion The cerebrospinal fluids＇ApoE polymorphism may be one of the factors affecting the brain edema in patients with contusion and laceration of brain.
作者 吴启华 钟志光 刘安民 朱钦龙 陈平 罗坚
机构地区 深圳市横岗人民医院脑外科 中山大学第二附属医院神经外科
出处 《中华神经外科疾病研究杂志》 CAS 2006年第4期346-348,共3页 Chinese Journal of Neurosurgical Disease Research
关键词 脑挫裂伤 脑脊液 载脂蛋白E 脑水肿 Contusion and laceration of brain Corebrospinal fluids Apolipoprotein E （ApoE） Brain edema
分类号 R651.15 [医药卫生—外科学]
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参考文献11

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共引文献108

同被引文献60

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中华神经外科疾病研究杂志
2006年 第4期

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