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气相色谱-质谱选择离子法评价系统性念珠菌感染与尿液中D/L阿拉伯糖醇比值的关系

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摘要 真菌代谢产物的检测在深部真菌感染诊断上的重要意义正成为近年关注的热点。阿拉伯糖醇是真菌代谢产物之一,与系统性念珠菌感染关系密切。它包括两种同分异构体:D-阿拉伯糖醇(D—arabinit01)和L-阿拉伯糖醇(L—arabinit01)。两者均可存在于正常人血液和尿液中,其中D-阿拉伯糖醇是大多数念珠菌的主要代谢产物。在系统性念珠菌感染时,血、尿中D-阿拉伯糖醇浓度会增高,L-阿拉伯糖醇并无明显增高,所以D/L-阿拉伯糖醇比值相应增高,可作为预测系统性念珠菌感染的一个指标。本研究采用气相色谱-质谱选择离子法检测系统性念珠菌感染和疑似感染者尿液中的D/L-阿拉伯糖醇比值.探讨临床系统性念珠菌感染与尿液中D/L-阿拉伯糖醇比值的关系。
出处 《中华皮肤科杂志》 CAS CSCD 北大核心 2006年第8期471-472,共2页 Chinese Journal of Dermatology
基金 国家自然科学基金(39970043)
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