神经生长因子治疗周围神经损伤的前瞻性研究

Effects of nerve growth factor on treatment of peripheral nerve injuries

目的观察神经生长因子(NGF)对周围神经损伤的近期治疗效果。方法2004年4月～2005年10月将48例周围神经损伤患者随机分为治疗组(NGF组,25例)和对照组(维生素B_(12)组,23例),4周后比较两组患者疼痛、麻木症状的改善情况,以及神经电生理变化。结果与对照组相比,治疗组患者的疼痛、麻木症状显著减轻,差异有显著性意义(P＜0．05)；感觉和运动电位的恢复率明显增高,差异有极显著性意义(P＜0．01)；恢复神经的感觉和运动电位的潜伏期均明显缩短,差异有显著性意义(P＜0．05)；波幅均显著增高,差异有显著性意义(P＜0．05),不良反应少。结论NGF早期可安全、有效地治疗周围神经损伤。

Objective To observe the effects of nerve growth factor （NGF） on the early treatment of peripheral nerve injuries. Methods From April 2004 to October 2005, 48 cases with peripheral nerve injury were randomly divided into therapeutic and control groups which were treated with NGF and Vitamin B12 for four weeks respectively. The changes in pain, numbness as well as neurophysiology in the two groups were assessed and compared. Results Compared with the control group, symptoms of pain and numbness in the therapeutic group were significantly alleviated （ P 〈 0.05）, the number of regenerative nerves was greater （ P 〈 0. 01）, latent periods for the recovered sensory and motorial potentials of the regenerative nerves shorter, amplitudes significantly higher （ P 〈 0. 05 ）, and side effects fewer. Conclusion NGF is safe and effective for early treatment of peripheral nerve injuries.