摘要
目的通过大鼠的行为学及海马β1和β2肾上腺素受体m RNA表达,研究重复经颅磁刺激(rT-M S)对大鼠抑郁症的治疗作用及其机制。方法通过比较抑郁症和非抑郁症大鼠在强迫游泳实验中的表现探讨大鼠的行为学变化;通过RT-PCR半定量法分析其海马β1和β2肾上腺素受体m RNA含量的变化。结果抑郁症大鼠海马的β1和β2肾上腺素受体m RNA表达增加;rTM S能够缩短抑郁症大鼠在强迫游泳实验中的悬浮时间,并减少其海马β1和β2肾上腺素受体m RNA的表达。结论rTM S对抑郁症有明显的治疗作用,且作用机制与海马β1和β2肾上腺素受体表达减少有关。
Objective To study the effect and mechanism of rTMS on learned helplessness（LH） rats. Method Seventeen LH rats and 20 non-LH rats were studied. Forced swimming test was performed to detect the behavior of the rats. Reverse transcription-polymerase chain reaction （RT-PCR） was used to observe the change of β1, and β2 adrenergic receptor mRNA expression in hippocampus in the rats. Result In depressive rats, the levels of β1 and β2 adrenergic receptor mRNA in hippocampus increased significantly. Motionless time in the forced swimming test and the levels of β1 and β2 adrenergic receptor mRNA in hippocampus were decreased significantly by rTMS. Conclusion rTMS exerts marked antidepressant effects, and the decreased β1 and β2 adrenergic receptor in hippocampus may play a role in the antidepressive mechanism of rTMS.
出处
《航天医学与医学工程》
CAS
CSCD
北大核心
2006年第4期297-300,共4页
Space Medicine & Medical Engineering
基金
国家自然科学基金资助(30470623
30070278)
关键词
重复经颅磁刺激
LH模型
强迫游泳实验
肾上腺素受体
repetitive transcranial magnetic stimulation
learned helplessness model
forced swimming test
adrenergic receptors
