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巨噬细胞移动抑制因子在脓毒性休克及其治疗中的作用 被引量：4

Role of macrophage migration inhibitory factor in mechanism and treatment of septic shock
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摘要 巨噬细胞移动抑制因子(M IF)是一种潜在的促炎细胞因子,是天然免疫和获得性免疫中的关键调节元件。该综述主要介绍M IF的组织细胞来源、基因结构、蛋白结构以及其生物活性、在脓毒性休克发病过程中的作用和拮抗M IF在脓毒性休克治疗中的作用。 Macrophage migration inhibitory factor （ MIF）, a potential pro -inflammatory cytokine, is a pivotal regulatory element in the nature and adapted immune. This article aims to introduce the histocellular sources, genetic structure, protein structure and biological activity of this cytokine, and further to explore its role in the pathogenesis of septic shock, and its antagonist in the treatment of this disease.
作者 郭建秀 胡川闽
机构地区 第三军医大学检验系临床生化学教研室
出处 《医学研究生学报》 CAS 2006年第8期748-751,756,共5页 Journal of Medical Postgraduates
基金 重庆市科委2004自然科学基金重点资助项目(批准号:2004BA5017) 创伤烧伤复合伤国家重点实验室开放基金资助项目(批准号:200317)
关键词 巨噬细胞移动抑制因子 细胞因子 脓毒性休克 Macrophage migration inhibitory factor Cytokine Septic shock
分类号 R392.11 [医药卫生—免疫学]
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参考文献23

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二级参考文献48

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医学研究生学报
2006年 第8期

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