异基因造血干细胞移植中NK细胞的作用

Role of NK Cells in Allogeneic Hematopoietic Stem Cell Transplantation——Review

异基因造血干细胞移植后,供者细胞可产生强大而持久的免疫治疗功效,其中异源反应性NK细胞活性是T细胞异源反应活性以外的,具有显著抗肿瘤/白血病活性的自然免疫现象,并逐渐受到人们的重视。已证实,NK细胞通过其受体与靶细胞MHC分子特异性的识别机制参与移植物抗白血病(GVL)作用并影响移植物抗宿主病(GVHD)的发生。异基因造血干细胞移植后异源反应性NK细胞输注已从动物实验逐渐应用于临床。本文就NK细胞异源反应性及其在异基因造血干细胞移植中的作用进行综述。

After allogeneic hematopoietic stem cell transplantation （allo-HSCT）, the donor cells present a profound immunization therapy efficiency. Among these effector cells, allo-reactivity natural killer （NK） cell activation are concerned with the graft-versus-host disease （GVHD） and graft-versus-leukemia （GVL） effect. As known, GVHD is pri- marily a T-cell-mediated event but not initiated by NK cells, NK cells may significantly enhance GVL immune response by using an integration of activating and inhibitory receptors. Allo-reactivitive NK cell infusion after allo-HSCT already transits from experiments to clinic. In this review the background on NK cells, and their clinical roles in Allo-HSCT were summarized.