紫苏不同部位提取物对大鼠血液流变性的影响

Effects of Extracts from Different Parts of Folium Perillae (L.) Britt.on Hemorrheological Parameters in Rats

研究了紫苏不同部位(苏叶、苏子、苏梗)提取物对血液流变学参数的影响,为药物开发和临床应用提供实验依据。实验结果表明:紫苏不同部位提取物都能显著降低低切时(10-s 1)的全血黏度、红细胞聚集指数和红细胞电泳指数(P<0.05),并能极显著降低低切时的全血还原黏度(P<0.01);苏叶、苏梗提取物能显著降低红细胞变形指数(P<0.05),而苏子提取物对红细胞变形指数无显著影响;苏子、苏梗提取物能显著降低血浆黏度(P<0.05),而苏叶提取物则不能降低血浆黏度;阿司匹林对照组只能显著降低低切时(10-s 1)全血还原黏度和血浆黏度(P<0.05)。紫苏不同部位提取物对中切和高切时(60-s 1,120-s 1)的全血黏度和全血还原黏度、红细胞压积、红细胞刚性指数、纤维蛋白原含量无显著影响(P>0.05)。

In order to provide experimental data for the development and application of drug in clinic, we determined the effects of extracts from different parts of folium perillae （L.） Britt. on hemorheological parameters, extracted from leaves （folium peHllae）, seeds （fructus peHllae） and peduncles （caulis perillae）. The results showed that all extracts from different parts of folium perillae （L.） Britt. can significantly reduce the whole blood viscosity at low shear rate（10 s^-1） , erythrocyte aggregation index, erythrocyte electrophoresis index （P〈0. 05）, and the whole blood reductive viscosity at low shear rate（10 s^-1） （P〈0. 01）. Extracts from folium perillae and caulis perillae can significantly decrease erythrocyte deformation index （P〈0. 05）, whereas extracts from fructus perillae can not. Extracts from fructus perillae and caulis perillae can significantly decrease plasma viscosity at low shear rate（10 s^-1）, but extracts of folium perillae can not. Aspirin can only decrease the whole blood reductive viscosity at low shear rate and plasma viscosity （P〈0. 05）. All extracts from different parts of folium perillae （L.） Britt. had no significant effects on hematocrit, erythrocyte rigidity index, fibrinogen concentration , the whole blood viscosity and the whole blood reductive viscosity at middle and high shear rate（60 s^-1,120 s^-1）.