体外模拟心血管系统血液动力学性能分析

Hemodynamics Study of Cardivoascular System In Vitro Simulation

为研究人工心脏和心血管系统之间的血液动力学作用机制,根据弹性腔模型建立了一套能反映血液动力学特性的体外血液循环模拟实验装置,测试血液动力学参量与心室后负荷(即外周力R和动脉顺应性C)以及每搏心输出量Vs,心动周期T和心室收缩时间间隔Ts,前负荷等六个参量之间的相互关系,通过改变六个参量中的某一个参量而固定其余参量,测试这个参量对动脉血压及流量的影响情况。实验结果与生理情况和数学模型分析相符合。压力和流量波呈脉动性,与真实生理波形相似。整个模拟装置能够反映血液动力学特性。

In order to study the cardiovascular hemodynamic characteristics and evaluate the blood pump, we made a series of cardiovascular simulation devices which could reflect the hemodynamics of blood circulation system by the elastic chamber model, and tested the relations between cardiovascular hemodynamic parameters （such as systole pressure, diastole pressure, average pressure, pulsative pressure, flow rate） and ventricular afterload （peripheral resistance and vacular compliance） as well as cardiac output, diastolic period, systole period and preload. The effect of the parameters on the arterial pressure and flow rate was estimated when any one of the parameters was changed. The result of simulating experiment was coincided with that deduced from mathematical model and physiologic condition. Therefore the series of cardiovascular simulation devices can reflect the hemodynamics of blood circulation.