脑源性神经营养因子诱导的丝裂原活化蛋白激酶信号通路

Ras-MAPK Signaling Pathway Activated via Brain-Derived Neurotrophic Factor

脑源性神经营养因子(B ra in-derived neurotroph ic factor,BDNF)是脑组织中含量最丰富的神经营养因子而且可能为一活性依赖性神经元存活因子。体外试验证实BDNF对正常皮质神经元有维持存活效应;对缺氧神经元有确切保护作用。它主要通过丝裂原活化蛋白激酶(M itogen-activated prote in k inase,M APK)信号通路及C a2+/钙调蛋白依赖性激酶(C a2+/C a lm odu lin-dependen t k inase,C aM K)信号通路调节脑细胞的生长、分化、存活、抗凋亡作用,而且其信号传导通路之间存在着复杂的交叉串扰机制。

Brain-derived neurotrophic factor （BDNF）is the richest neurophin in brain tissue and may act as an activity-dependent neuronal survival factor. In vitro, BDNF plays an important role in preventing cortical neurons from hypoxia-induced neurotoxicity. It could induce a variety of cellular responses such as cell growth,survival, differentiation, and anti-apoptosis mainly via activating mitogen-activated protein kinase （MAPK） and Ca^2＋/ calmodulin-dependent kinase （CaMK）signaling pathways. And among these multiple signaling pathways there is growing evidence of complicated cross talk.