摘要
目的:探讨浅表性膀胱癌组织学形态以及Ki67、p63表达与肿瘤复发的关系。方法:将3年来随访的60例浅表性膀胱癌分为复发组和无复发组。免疫组化法检测Ki-67和p63的表达并比较复发组与无复发组的差异。结果:在平均28个月的随访中,40例复发,复发1~4次,Ki-67和p63阳性率在两组之间有明显差别,复发组均明显高于无复发组(P〈0.05)。在不同病理分级TCC中p63和Ki-67表达有明显差异,病理分级高的明显高于分级低的(P〈0.01)。结论:Ki-67、p63阳性表达尤其是联合阳性表达对判断膀胱癌复发具有重要意义。
Objective:To approach the correlation between histology manifestation or Ki-67, p63 expression and superficial bladder cancer. Methods:60 cases of superficial bladder cancer(the average duration of follow up survey for the patients was about 3 years) were classified into two groups (with and without recurrence) . The expression of both Ki-67 and p63 was detected with immunohistochemical method , and a comparison was made between with and without recurrence group. Results:The average duration of follow up survey for the patients was 28 months. There were 40 cases of superficial bladder cancer with recurrence(about 1-4). There was a significant difference in Ki-67 and p63 expression between the recurrence and non-recurrence groups ,the positive rate in recurrence group was significantly higher than that in non-recurrence group ( P 〈0.05). Among the cases of papillary carcinoma , the recurrence rate in the cases with combined Ki-67 and p63 expression was significantly higher than that in the cases with only Ki-67 or p63 expression alone. Conclnsions:The expression of Ki-67 and p63, especially the positive combined expression played an important role in the judgment of recurrence.
出处
《临床泌尿外科杂志》
2006年第8期598-600,共3页
Journal of Clinical Urology