髓鞘碱性蛋白和白细胞介素16在多发性硬化发病机制和临床中的探讨

Investigation of Myelin Basic Protein and IL-16 in Patients with Multiple Sclerosis

目的探讨髓鞘碱性蛋白(MBP)和白细胞介素16(IL-16)在多发性硬化(MS)发病过程中的水平变化和临床意义。方法用ELISA法检测MS组(CSF31例、Serum32例)、Guillain-Barre综合征(GBS)组(CSF和Serum均为24例)和对照组(CSF24例、Serum28例)中MBP和IL-16的水平。结果MS组中CSF和Serum中MBP水平均显著高于GBS及对照组(P<0.01),CSFIL-16的水平显著高于对照组(P<0.01),但SerumIL-16水平和对照组相比无明显差异性。MS组CSF中MBP的水平和IL-16的水平显著相关(r=0.463,P<0.05),但Serum中两者间无相关性。结论MBP对MS的发病有很高的敏感性,IL-16主要在中枢神经系统局部产生并参与MS的炎症过程。

Objective To determine the levels and significance of myelin basic protein （MBP） and intedeukin 16 （IL-16） in patients with multiple sclerosis （MS）. Method The levels of MBP and IL-16 were measured in patients with MS （CSF 31 cases; serum 32 cases）, Guillain-Barre syndrome （GBS; CSF 24 cases, serum 24 cases） and in control subjects（CSF 24 cases; serum 28 cases） by ELISA method. Result The levels of MBP in CSF and scram were increased significantly in MS patients compared with those in GBS or control subjects （P 〈 0.01）. Levels of IL-16 in CSF also increased significantly in MS patients compared with the control subjects（P 〈 0.01）, but no difference was found in serum between MS and control subjects. The concentration of MBP in CSF correlated with the level of IL-16 in CSF （r=0.463, P 〈 0.05）, but no correlation was found between the concentrations of MBP and IL-16 in serum. Conclusion MBP can be detected during the onset of MS. IL-16 is mainly induced within CNS and participates in the inflammation of MS.