广州市企事业单位成人脂肪肝患病率及其危险因素的探讨

Prevalence and Risk Factors of Fatty Liver in Guangzhou Enterprises

目的探讨广州市企事业单位成人脂肪肝患病率及其危险因素及预防发病的干预措施。方法采用随机分层抽样的方法对6272例2005年6～12月在我院健康体检的广州市企事业单位成人体检资料进行统计分析,内容包括体格检查、空腹血糖测定及肝胆B超。结果6272名成人研究对象中,男性3662名,女性2610人,平均年龄(46.43±13.7)岁。B超共检出脂肪肝1369人,患病率为21.83%,男性为24.47%,女性为18.12%。男性患病率显著高于女性(χ2=35.96,P<0.01)。男女脂肪肝患病率均随年龄增长而增加,58岁前男性患病率显著高于女性(χ2=18.7,P<0.01),58～70岁之间男女性患病率无显著性差异(χ2=0.67,P=0.43),70岁后女性脂肪肝患病率显著高于男性(χ2=5.3,P<0.05)。脂肪肝组肥胖、血脂异常、空腹血糖增高和胆石症均显著高于非脂肪肝组。结论广州市企事业单位成人脂肪肝患病率高,肥胖、血脂异常、空腹血糖增高和胆石症可能是其危险因素。

Objective To investigate the prevalence, risk factors and preventive measurements of fatty liver in Guangzhou enterprises. Method Medical check up data of adult staff of the Guangzhou enterprises, including physical examination, fasting blood glucose, and type B ultrasonographic examination of liver were collected and analyzed. Result 6272 individuals （3662 males and 2610 females） with an average age of 46.43 years （46.43±13.7） were investigated. 1369 cases with fatty liver were detected by ultrasonograhic examination, with prevalence rate of 21.83%, among which males accounted for 24.7% and females 18.12%. The prevalence rate of male was significantly higher than that of female （x^2=35.96,P〈 0.01）. The prevalence rate increased with the increased in age in both gender. Before the age of 58, the prevalence rate of male was higher than that of female （x^2=18.7,P〈 0.01）. There was no significant difference in the prevalence rate of male and female between age 58 to 70. The prevalence rate of females was higher than that of males after age 70 （x^2=5.3 ,P〈 0.05）. The rate of obesity, blood cholesterol level, fasting blood glucose level and choleithiasis occurrence were higher in the people with fatty liver than those without fatty liver. Conclusion There is a high prevalence of fatty liver among adult staff of Guangzhou enterprises, which may be correlated to obesity, high blood chorestrol level, high fasting blood glucose level and choleithiasis.