L－精氨酸对兔血脂和脂蛋白（a）水平的影响

Effect of L-arginine on the levels of blood lipid and lipoprotein (a) in hypercholesterolemic rabbits

４０只雄兔随机等分为４组：正常对照组（ＮＣ）、高胆固醇血症组（ＨＣ）、氯贝丁酯组（ＣＬ）和Ｌ－精氨酸组（Ｌ－ａｒｇ），实验前及治疗１０周从各组动物耳中央动脉抽血（空腹），酶法检测血清总胆固醇（ＴＣ）、甘油三酯（ＴＧ）、高密度脂蛋白胆固醇（ＨＤＬ－Ｃ），ＥＬＩＳＡ法检测脂蛋白（ａ）［Ｌｐ（ａ）］。结果：治疗１０周Ｌ－ａｒｇ组与ＨＣ组ＴＣ无差异（Ｐ＞０．１０），但ＣＬ组ＴＣ明显低于ＨＣ组（Ｐ＜０．０５）。实验１０周ＣＬ组和ＨＣ组的Ｌｐ（ａ）明显高于实验前（Ｐ＜０．０５），虽然实验前后Ｌ－ａｒｇ组的Ｌｐ（ａ）变化不大，但实验１０周时Ｌ－ａｒｇ组和ＨＣ组的Ｌｐ（ａ）有极显著差异，Ｌ－ａｒｇ组低于ＨＣ组（Ｐ＜０．０５）。提示：同ＣＬ组相比，Ｌ－精氨酸虽不降低血清总胆固醇，但对Ｌｐ（ａ）有显著影响。

Forty male rabbits were divided at random into four groups: L-arginine group(L-arg),clofibrate group(CL), hypercholesterolemic group(HC) and normal control group(NC).Before. the experiment and after 10 weeks of treatemnt, the blood samples were collected from the rabbits in each group for the measurement of the total cholesterol(TC) in plasma,triglyceride(TG), high density lipoprotein cholesterol (HDL-C), and lipoprotein (a)[Lp (a)]. The experimental results showed that after 10 weeks of treatment, the TC in the L-Arg group had no difference from that in the HC group (P> 0.1), but the TC in the CL group was significantly less than that in the HC group (P< 0. 05 ). The Lp(a)in the CL group or in the HC group after 10 weeks of treatment was significantly higher than that before the experiment(P<0.05). Although the Lp(a) in the L-arg group before and after the experiment had no alteration, at the 10th week of treatment the Lp(a) in the L-arg group was significantly less than that in the HC group (P<0. 05). The study suggested that,in contrast with the CL group, L-arginine didn't reduce the serum total cholesterol concentration, but greatly influenced the serum Lp(a) concentration.