摘要
目的:探讨不同分化程度胃癌细胞对艾恒、5-FU、MMC和VP-16的敏感性。方法:将不同浓度的化疗药物与两株不同分化程度的胃癌细胞株共同温育,采用MTT方法检测化疗各药物对胃癌细胞增殖的影响。结果:四种化疗药物对两株胃癌细胞的增殖均具有显著的抑制作用,MKN45细胞株对各化疗药物敏感性顺序为:MMC>VP-16>艾恒>5-FU,而SGC7901细胞株对各化疗药物敏感性顺序为:MMC>艾恒>VP-16>5-FU。中分化的SGC7901对艾恒、MMC、VP-16的敏感性均显著高于低分化的MKN45,而MKN45对5-FU的敏感性高于SGC7901。结论:不同分化程度的胃癌细胞对药物的敏感性不同。
Objective: To investigate the sensitivity of Oxaliplatin, 5-FU,MMC and VP-16 in gastric cancer cell lines. Methods:Two gastric cancer cell lines with various degrees of differentiation were incubated with chemotherapy drugs of various concentration. The cytotoxicity was examined by MTr test. Results: All of Oxaliplatin, 5-FU, MMC and VP-16 had significant killing effect on human gastric cancer cells in vitro. Chemosensitivity sequence for single drug in poorly differentiated gastric cancer cell line MKN45 was MMC 〉 VP-16 〉 L-OHP 〉 5-FU, and that in moderately differentiated gastric cancer cell line SGC'7901 was MMC 〉 L-OHP 〉 VP-16 〉 5-FU. SGC7901 is more sensitive to L-OHP, MMC, VP-16 but MKN45 is more sensitive to 5-FU. Conclusion: The effect of chemotherapy drugs on gastric cancer cells was different among 2 cemines.
出处
《军医进修学院学报》
CAS
北大核心
2006年第4期290-291,共2页
Academic Journal of Pla Postgraduate Medical School
关键词
艾恒
胃肿瘤
oxaliplatin
stamach neoplasms