肺癌患者血浆中神经调节肽的变化

Changes of Substance P and Somatostatin in Patients with Lung Cancer

测定58例未经治疗的肺癌患者(包括腺癌28例、小细胞肺癌20例、鳞癌10例)血浆中P物质(SP)、生长抑素(SS)的浓度。结果表明,肺癌患者血浆中SP、SS含量分别比正常人升高1.8倍和2.1倍。肺癌早期SP、SS浓度即高于正常人,肺癌晚期明显高于肺癌早期。鳞癌、腺癌、小细胞肺癌间血浆中SP、SS含量无明显差异。

Substance P(SP)and somatostatin(SS)in plasma were measured in 58 untreated patients with lung cancer (28 cases of adenocarcinoma,20 small cell lung cancer, 10 squamous carcinoma). The results showed that blood contents of SP and SS in lung cancer patients were much higher than those in normal controls,and these indices in early stage of lung cancer were lower than those in advanced stage. There were no significant differences for these indices among three types of cancer. High levels of SP and SS suggested that cellular immunity decreased in patients with lung cancer.