梗阻性黄疸患者免疫功能变化及转归——Ⅱ.T淋巴细胞亚群研究

Changes of Humoral and Cellular Immunity in Obstructive Jaundice Patients II. A Study on T Lymphocyte Subpopulation

研究了37例梗阻性黄疸(A组)和90例单纯胆囊结石(D组)T汗淋巴细胞亚群,讨论梗阻性黄疸患者T淋巴细胞变化与胆道压力的关系。A组分为急诊手术(B组)和择期手术(C组)。结果显示A～C组术前CD_8^+、CD_4^+、CD_8^+、CD_4^+/CD_8^+显著低于术后8～12天(P<0.05或P<0.01)。D组术前CD_3^+、CD_4^+、CD_9^+显著低于术后3～7天(P<0.01),术前A组CD_8^+、CD_4^+/CD_8^+显著低于D组(P<0.05),CD_3^+、CD_2^+无显著性差异(P>0.05)。BTP与CD_3^+、CD_8^+、CD_8^+呈负相关(P<0.05,或P<0.01)。因此,作者认为梗阻性黄疽患者T淋巴细胞亚群处于抑制状态。及时解除胆道梗阻是恢复机体T淋巴细胞功能的关键。

T lymphocyte subpopulations were studied in 37 patients with obstructive jaundice (group A)and 90 cases with simple gallstones (group D). Relationship between T lymphocyte subpopulation and biliary tract pressure was discussed. Group A was subgrouped into emergency operation (group B)and elective one (group C). The results showed that CD3+ ,CD4+,CD8+ and CD4+/CD8+ were lower in pre-operation than those of post-operation 8-12 days in obstructive jaundice patients(P<0. 05 ,or P<0. 01). CD3+. CD4+ ,CD8+ were lower in pre-operation than those of post-operation 3~7 days in group D(P<<0.01). CD4+ ,CD4+/CD8+ were lower in group A than those of group D(P<0. 05) ,and the levels of CD3+,CD8+ of groups A and D were not signifcantly different (P> 0. 05 ) in preoperation. Regressive analysis showed that the biliary tract pressure was negatively related with CD3+ ,CD4+ ,and CD8+ (P<0. 05 or P <0. 01). Therefore,it was suggested that T lymphocyte subpopulation functions were suppressed by obstructive jaundice.