旋覆代赭汤对酸性反流性食管炎模型大鼠胃窦黏膜胃泌素表达的影响

Effect of XUAN FU DAI ZHE Decoction on Gastrin Expression from Gastric Antrum of Rats with Acid Reflux Esophagitis

[目的]观察旋覆代赭汤对酸性反流性食管炎模型大鼠胃窦黏膜胃泌素表达的影响。[方法]用不全幽门结扎+食管下括约肌(LES)切开术制备酸性反流性食管炎大鼠模型后,给予旋覆代赭汤水煎剂,分别于治疗2、4、8d后观察各组大鼠胃窦黏膜胃泌素表达的变化。[结果]用旋覆代赭汤治疗8d后,胃窦黏膜胃泌素的表达即有所提高,并与假手术对照组相比无显著性差异(P>0.05)。[结论]旋覆代赭汤在治疗酸性反流性食管炎的过程中,能够明显增强胃窦黏膜胃泌素的表达,从而可促进LES功能的恢复,增加LES的压力,防止酸反流,促进疾病的恢复。

[Objective] To observe the effect of XUAN FU（Flos inulae）DAI ZHE（Haematitum） decoction on the expression of gastrin from the mucous membrane of gastric antrum in rats with acid reflux esophagitis. [Methods] The acid reflux esophagitis was induced by partial ligation of the pylorus and inferior esophageal sphincterotomy. Two, four and eight days after administration of XUAN FU DAI ZHE decoction the changes of the secretion of gastrin from the mucosa of gastric antrum were observed. [Results] There was obvious improvement for the gastrin expression 8 days after treating without significant difference when compared with the sham operation group（P〉0.05）. [Conclusions] The XUAN FU DAI ZHE decoction can increase the gastrin expression and thus improving the recovery of the function of LES and increasing the pressure on LES, preventing the reflux of gastric acid and accelerating and making a quick convalence.