新生儿缺氧缺血性脑病血清神经元特异性烯醇化酶和头颅CT的变化

The changes of serum neuro-specific enolase and cranial CT in neonatal hypoxic ischemic encephalopathy

目的探讨血清神经元特异性烯醇化酶（ＮＳＥ）和头颅ＣＴ在新生儿缺氧缺血性脑病（ＨＩＥ）诊断中的作用。方法ＨＩＲ患儿２０例，用酶联免疫法测定生后８天、７天血清ＮＳＥ浓度。生后１周内行头颅ＣＴ检查。结果ＨＩＥ患儿血清ＮＳＥ在生后３天均升高，尤以中、重度明显，与临床分度一致。重度ＨＩＥ患儿头颅ＣＴ分度与临床一致，轻、中度头颅ＣＴ分度与临床不平行。结论血清ＮＳＥ测定是早期诊断ＨＩＥ及判断脑损伤的有效指标，头颅ＣＴ检查结合血清ＮＳＥ测定可更为准确地帮助ＨＩＥ的诊断和治疗。

To search for the changes of serum neurospecific enolase (NSE) concentration and cranial CT sean in the neonatal hypoxic ischemic encephalopathy (HIE).Methods Twenty neonates of HIE were examined.The concentration of serum NSE was measured by enzyme-linked immunosorbent assay (ELISA) of 3 days and 7 days of life.The cranial CT sean was examined in the first week of life.Results The concentrations of serum NSE at 3 days of life increased in 20 HIE neonates, especilly in moderate and heavy ones, and they were identical with the clinical manifestation.The cramal CT scan showed no differences with the clinical manifestation in them in the light and moderate ones.Conclusions NSE is a reliable marker for early diagnosis of HIE and estimate of hypoxic-ischemic brain damage. The cranial CT saan together with serum NSf are much help for the diagnosis and cure of HIE.